History of RHSP

The Rakai Health Sciences Program (RHSP) was established in 1987 as a collaboration between researchers at Makerere, Columbia and John Hopkins Universities, the Division of Intramural Research at the National Institutes of Allergy & Infectious diseases and the International Centre for Excellence Research (ICER). This was as a result of the first identification of clinical AIDS in Rakai district Uganda in 1982 by Drs. Sewankambo and Serwadda. The initiation of the Program, then known as Rakai Project led to a series of clinical studies characterizing the disease and its epidemiology; and also brought the partnership with other colleagues including Professor Maria Wawer and Prof Ronald Gray.

 

Rakai Health Sciences Program (RHSP) Timeline

MonthDayYearEventCategoryDescription Document/sourceKey people
  1982first case of Slim Disease identified in RakaiOtherSlim disease, characterized by extreme wasting and weight loss, was identified in Rakai districtSerwaada et al 1985 
  1986President Museveni came into powerOther   
8 1987Wawer first arrived in RakaiOther   
  1987ABC AIDS control program was establishedOtherABC program (Abstain, Be faithful, use Condoms) established in Uganda to promote HIV preventionwww.avert.org/hiv-aids-uganda.htm 
  1987National Committee for the Prevention of AIDS launchedOtherMOH established this committee to start a health education campaign on the radio, TV, and local press. "Love Carefully" campaignHooper et al 1987 
  1988Rakai Cohort began (USAID)StudiesPopulation-based cohort study initiated to collect longitudinal data on HIV epidemiology and socioeconomic effects of the epidemic. Started with 21 clusters of 30 households each, (population=1800) Global information and education on HIV and AIDS  
  1989HIV Dynamics Study funded by NIHFundingNIH funds HIV Dynamics Study for 3 years; allows Rakai Cohort to expandFred Nalugoda, Julia Cummiskey 
  1989Kalisizo field station sets up lab resources for sample preparationLab testsThe capacity of the lab in Kalisizo is limited to to syphilis by RPR with confirmatory TPPA or TPHA. Serum samples frozen and shipped in bulk to UVRI for HIV ELISA testingSarah, Margaret - lab 
  1989Serologic testing by ELISA, confirmatory testing by Western blot for HIV testingLab testsHIV serologic testing by ELISA(Recombigen); positive tests confirmed by Western Blot (Biorad) at UVRIBerkley et al 1990 
  1989Rakai Cohort expanded (NIH)Studies31 clusters, population=4000www.jhsph.edu/research/centers-and-institutes/rakai-health-sciences-program 
  1990counseling, health, and education funded by Rockefeller Foundation and NIHFundingRockefeller Foundation and NIH fund establishment of counseling, health, and educationFred Nalugoda, Julia Cummiskey 
  1990Rakai AIDS Information Network funded by DANIDA and USAIDFundingDANIDA and USAID fund establishment of program by Rakai Project. Began as a NGOFred Nalugoda, Julia Cummiskey 
  1992Sexual Networks Study funded by NIHFundingfunded for 3 yearsFred Nalugoda, Julia Cummiskey 
  1992Preparation for AIDS Vaccine Evaluation (PAVE) funded by NIHFundingfunded for 2 yearsFred Nalugoda, Julia Cummiskey 
  1992Rakai cohort funded by WHOFundingfunded for 1 yearFred Nalugoda, Julia Cummiskey 
  1992family planning funded by MellonFundingMellon foundation funds family planning 1992-1996Fred Nalugoda, Julia Cummiskey 
  1992International AIDS Initiative funded by Rockefeller FoundationFundingRF funds 4 year operations reseach on HIV prevention, evaluating health education, risk reduction, condom acceptance & use, HIV testingRHSP Status Report Feb 2007, Fred Nalugoda 
  1993MOH provides funding for STD controlFundingUnder AIDS control program, MOH provides funding to treat STDs.Fred Nalugoda 
  1993Training grants funded by Fogarty InternationalFunding Fred Nalugoda, Julia Cummiskey 
  1993PAVE study beganStudiesCommunity mapping project that would enable locating communities that would be appropriate to follow for STD Control Trial. Initial study lasted 1 year.Fred Nalugoda 
2211994RCCS cohort A1 beganStudiesRange: 21 Feb 1994-17 Dec 1995Regions and Communities 
11 1994STD design questionnaire createdQuestionnairesBaseline, f/u versions created for m, f, transients <6 months (m or f). Questionnaires administered at baseline, 1 year, every year thereafter for 5 years. Functioned as first questionnaire of the Rakai cohort. Assessed demographics, social and sexual behaviors, health status, care seeking, coital frequency. Longest form of cohort questionnaire to be administeredQC team 
  1994KYOTERA (001) 004 PickCommunitiesKASAMBYA picked up during A1 (1994-1995)Regions and Communities 
  1994KYOTERA (001) 024 PickCommunitiesBBIBIRO, Kamwanyi, Kinyankole, Kabaseke picked up during A1 (1994-1995)Regions and Communities 
  1994KYOTERA (001) 074 PickCommunitiesKYAKKONDA, Kiweesa picked up during A1 (1994-1995)Regions and Communities 
  1994KYOTERA (001) 754 PickCommunitiesBUYAMBI\KASAALI, Kifukamiza, Kigenya picked up during A1 (1994-1995)Regions and Communities 
  1994KYOTERA (001) 755 PickCommunitiesKIBIRA, Bijja, Bikira, Gayaza, Kiteredde picked up during A1 (1994-1995)Regions and Communities 
  1994KALISIZO (002) 005 PickCommunitiesNSAMBYA, Kakoma, Miti, Kirinda picked up during A1 (1994-1995)Regions and Communities 
  1994KALISIZO (002) 006 PickCommunitiesMITONDO\KYANGO picked up during A1 (1994-1995)Regions and Communities 
  1994KALISIZO (002) 029 PickCommunitiesMANYAMA, Kalangala, Kamaggwa picked up during A1 (1994-1995)Regions and Communities 
  1994KALISIZO (002) 062 PickCommunitiesLUSAKA, Vvuma picked up during A1 (1994-1995)Regions and Communities 
  1994KALISIZO (002) 067 PickCommunitiesKINAAWA, Matale picked up during A1 (1994-1995)Regions and Communities 
  1994KALISIZO (002) 077 PickCommunitiesKALAGALA, Bulengeza picked up during A1 (1994-1995)Regions and Communities 
  1994KALISIZO (002) 120 PickCommunitiesKIKUNGWE, Kawuwa picked up during A1 (1994-1995)Regions and Communities 
  1994KIBALE\RAKAI (003) 036 PickCommunitiesKYAKAGO/KIBANDA, Bushenyi, Bulanga picked up during A1 (1994-1995)Regions and Communities 
  1994KIBALE\RAKAI (003) 044 PickCommunitiesKIBAALE TC. Picked up during A1 (1994-1995)Regions and Communities 
  1994KIBALE\RAKAI (003) 055 PickCommunitiesBYAKABANDA, Kageye, Kyandaaza Katerero picked up during A1 (1994-1995)Regions and Communities 
  1994KIBALE\RAKAI (003) 084 PickCommunitiesRAKAI TC. Picked up during A1 (1994-1995)Regions and Communities 
  1994KIBALE\RAKAI (003) 401 PickCommunitiesBAKIJJULULA, Kamukalo picked up during A1 (1994-1995)Regions and Communities 
  1994KABIRA (004) 007 PickCommunitiesKACHANGA, Kyanika, Kakoni Lwabawambya picked up during A1 (1994-1995)Regions and Communities 
  1994KABIRA (004) 008 PickCommunitiesKABIRA/KIFUUTA picked up during A1 (1994-1995)Regions and Communities 
  1994KABIRA (004) 106 PickCommunitiesKABAWANGA, Kiwumulo, Misoto, Biafra ndeeba picked up during A1 (1994-1995)Regions and Communities 
  1994KAKUUTO (005) 002 PickCommunitiesKAKUUTO, Kitasiba picked up during A1 (1994-1995)Regions and Communities 
  1994KAKUUTO (005) 016 PickCommunitiesKANGABWA, Kalivario picked up during A1 (1994-1995)Regions and Communities 
  1994KAKUUTO (005) 033 PickCommunitiesKABONERA picked up during A1 (1994-1995)Regions and Communities 
  1994KAKUUTO (005) 107 PickCommunitiesKIBAALE/SSANJE, Kannamiti, Mayanja, Katovu picked up during A1 (1994-1995)Regions and Communities 
  1994KATANA (006) 003 PickCommunitiesKATANA, Buzirandulu, Nvubu, Kirembwe, Kijej picked up during A1 (1994-1995)Regions and Communities 
  1994KATANA (006) 061 PickCommunitiesKIRUMBA, Kyakalera, Kabasumba, Butembe picked up during A1 (1994-1995)Regions and Communities 
  1994KATANA (006) 065 PickCommunitiesKYAKUDDUSE, Kasambya, Nkenge picked up during A1 (1994-1995)Regions and Communities 
  1994KATANA (006) 095 PickCommunitiesNABIGASA-Kafunda, Ntovu picked up during A1 (1994-1995)Regions and Communities 
  1994KATANA (006) 109 PickCommunitiesNAKATOOGO-East+West, Byerima, Nakasoga picked up during A1 (1994-1995)Regions and Communities 
  1994KATANA (006) 177 PickCommunitiesBETEREMU, Kituntu, Kibonzi, Kasekere, Kasambya picked up during A1 (1994-1995)Regions and Communities 
  1994KATANA (006) 256 PickCommunitiesKITO-NKOKKO, Kasaka, Lutoma picked up during A1 (1994-1995)Regions and Communities 
  1994BUYAMBA (007) 018 PickCommunitiesKICHWAMANGO, Luwama, Kasansula, Kisaana picked up during A1 (1994-1995)Regions and Communities 
  1994BUYAMBA (007) 025 PickCommunitiesBUYAMBA, Kyondo, Kammengo, Nsonso picked up during A1 (1994-1995)Regions and Communities 
  1994BUYAMBA (007) 059 PickCommunitiesDDWANIRO, Katonto, Kireeta Ntimbe Lutub, Nateete Lutilwanjuki picked up during A1 (1994-1995)Regions and Communities 
  1994BUYAMBA (007) 060 PickCommunitiesKISAAYITC picked up during A1 (1994-1995)Regions and Communities 
  1994BUYAMBA (007) 103 PickCommunitiesKIKUNYU, Kareere A+B picked up during A1 (1994-1995)Regions and Communities 
  1994BUYAMBA (007) 451 PickCommunitiesKAGAMBA,Kimuli picked up during A1 (1994-1995)Regions and Communities 
  1994LWANDA (008) 019 PickCommunitiesLUTEEBE, Kijjumba, Mpaama, Kikakata, Mukunyu, Kanoni, Kakek picked up during A1 (1994-1995)Regions and Communities 
  1994LWANDA (008) 032 PickCommunitiesBUTIITI TC. Picked up during A1 (1994-1995)Regions and Communities 
  1994LWANDA (008) 035 PickCommunitiesLWANDA TC. Picked up during A1 (1994-1995)Regions and Communities 
  1994LWANDA (008) 057 PickCommunitiesMBUYE, Derinya, Kengobe picked up during A1 (1994-1995)Regions and Communities 
  1994LWANDA (008) 602 PickCommunitiesBITABAGO, Lumbugu, Butula, Kirundamaliga, Nsozibbiri, Kikuula picked up during A1 (1994-1995)Regions and Communities 
  1994KASASA/SANJE (009) 034 PickCommunitiesKIFAMBA, Kagongero, Mmanya, Kitente picked up during A1 (1994-1995)Regions and Communities 
  1994KASASA/SANJE (009) 040 PickCommunitiesSSANJE, Kabano picked up during A1 (1994-1995)Regions and Communities 
  1994KASASA/SANJE (009) 056 PickCommunitiesKIGANDA, Lukyamu picked up during A1 (1994-1995)Regions and Communities 
  1994KASASA/SANJE (009) 058 PickCommunitiesLUTEETE picked up during A1 (1994-1995)Regions and Communities 
  1994KASASA/SANJE (009) 089 PickCommunitiesKIMUKUNDA, Kalungi, Kisalizi picked up during A1 (1994-1995)Regions and Communities 
  1994KASASA/SANJE (009) 094 PickCommunitiesMITYEBIRI picked up during A1 (1994-1995)Regions and Communities 
  1994KASASA/SANJE (009) 108 PickCommunitiesMBIRIZI, Kabala, Kasaasa picked up during A1 (1994-1995)Regions and Communities 
  1994KASASA/SANJE (009) 391 PickCommunitiesKASASA picked up during A1 (1994-1995)Regions and Communities 
  1994LWAMAGGWA (010) 052 PickCommunitiesLWENTULEGE, Kyaluyimuka picked up during A1 (1994-1995)Regions and Communities 
  1994LWAMAGGWA (010) 053 PickCommunitiesKAAPA KASAMBYA picked up during A1 (1994-1995)Regions and Communities 
  1994LWAMAGGWA (010) 054 PickCommunitiesNDEEBA\KATOOGO, Kyabigondo, Kayunga, Lwennanga picked up during A1 (1994-1995)Regions and Communities 
  1994LWAMAGGWA (010) 081 PickCommunitiesLWAMAGGWA picked up during A1 (1994-1995)Regions and Communities 
  1994LWAMAGGWA (010) 468 PickCommunitiesKACHERA, Kibaati, Katovu, Buyojwa picked up during A1 (1994-1995)Regions and Communities 
  1994LWAMAGGWA (010) 760 PickCommunitiesKASANKALA picked up during A1 (1994-1995)Regions and Communities 
  1994STD Control Trial funded by NIHFundingNIH extended funding for establishment of STD Control Trial for AIDS prevention for 5 years. Provides funding to follow Rakai cohort participantsRHSP Status Report Feb 2007, Fred Nalugoda 
  1994STD testing capability expands at Kalisizo field stationLab testsKalisizo field station increases capabilities to test for more STDs on site in preparation for STD Control Trial. In addition to syphilis, can perform CT/GC, trichimoniasis testing and BV slide reading. Serum samples frozen and shipped in bulk to Entebbe for HIV ELISA testing and further processingSarah, Margaret - lab 
  1994Parallel EIA, Discordant: WB for HIV testingLab testsTwo EIA's were run in parallel and discordants run on WBHistory of HIV Testing Algorithms 
  1994RCCS Verbal autopsies beganQuestionnaireswhen a person enrolled in the RCCS cohort dies, interviewer to use questionnaire to collect information about recently deceased person from their family members. Limited scope of questions focused on what people are dying from, symptoms at time of death, course of care.QC team, Fred Nalugoda 
  1994STD Control Trial beganStudiesHypothesized that by controlling STIs in the Rakai population, the spread of HIV transmission would be reducedRHSP status report Feb 2007 
3 1995Questionnaire for MISS study createdQuestionnairesIf person deemed eligible for MISS study after RCCS questionnaire, had additional MISS study questionnaire administered, with questions regarding birth and child development. Followed at enrollment, birth, 4 week f/u, every 1 year thereafter QC team 
8211995RCCS cohort A6 beganStudiesRange: 21 Aug 1995-8 Aug 1996Regions and Communities 
  1995KALISIZO (002) 067 DropCommunitiesKINAAWA, Matale dropped during A6 (1995-1996)Regions and Communities 
  1995KIBALE\RAKAI (003) 901 PickCommunitiesRAKAI HIGH S.S.S picked up during A6 (1995-1996)Regions and Communities 
  1995KATANA (006) 256 DropCommunitiesKITO-NKOKKO, Kasaka, Lutoma dropped during A6 (1995-1996)Regions and Communities 
  1995LWANDA (008) 900 PickCommunitiesKAMMENGO TECH.INST. Picked up during A6 (1995-1996)Regions and Communities 
  1995Maternal Infant Supplementary Study (MISS) funded by World Bank, Elizabeth Glaser Pediatric AIDS Foundation, NIHFunding4 years of funding for establishment of MISS, study to be nested into STD Control TrialRHSP Status Report Feb 2007, Fred Nalugoda 
  1995MISS study beganStudiesMaternal Infant supplementary study aimed to measure the effects of STD control during pregnany as a means of preventing maternal HIV/STI acquisition and pMTCT. RCT in which mothers received either comprehensive STI treatment or treatment for intestinal worms.RHSP Status Report Feb 2007, Fred Nalugoda 
6131996RCCS cohort B1 beganStudiesRange: 13 Jun 1996-30 May 1997Regions and Communities 
  1996KALISIZO (002) 951 PickCommunitiesRD.WKR KLZ-BIKIRA RD picked up during B1 (1996-1997)Regions and Communities 
  1996KASASA/SANJE (009) 950 PickCommunitiesRD. WKR SSANJE KIBAALE RD picked up during B1 (1996-1997)Regions and Communities 
661997RCCS cohort B6 beganStudiesRange: 6 Jun 1997 - 8 Oct 1998Regions and Communities 
  1997KALISIZO (002) 951 DropCommunitiesRD.WKR KLZ-BIKIRA RD dropped during B6 (1997-1998)Regions and Communities 
  1997KASASA/SANJE (009) 950 DropCommunitiesRD. WKR SSANJE KIBAALE RD dropped during B6 (1997-1998)Regions and Communities 
  1997MISS Study receives additional funding from USAID/Mother CareFunding RHSP Status Report Feb 2007, Fred Nalugoda 
551998RCCS cohort C1 beganStudiesRange: 5 May 1998 - 29 Mar 1999Regions and Communities 
  1998Family planning funded by Gates FoundationFundingGiven poor community knowledge of family planning practices, funding provided resources for intensive education, counseling, and materials for family planningFred Nalugoda 
  1998HSV-2 testing funded by Glaxo WelcomeFunding www.jhsph.edu/research/centers-and-institutes/rakai-health-sciences-program 
  1998Drug Access Initiative Began HIV CareLimited ART available in Uganda  
  1998Cohort questionnaire truncatedQuestionnairesWhen STD control trial ended, cohort questionnaire was truncated and less people were evaluated. Main clients in follow up were pregnant women who were followed to evaluate effect of STDs on pregnancy, mother, and childFred Nalugoda 
  1998Family planning outreach beganStudiesUse community reproductive health workers to improve family planning uptake through intensive education and counselingFred Nalugoda 
  1998Adolescent family planning study beganStudiesInfrastructure for adolescent STD care services established for 2 years, and allowed for RCT to evaluate effect of intensive family planning education on adolescentsFred Nalugoda 
4 1999CHER study beganStudiesCommunity HIV Epidemiological Research (CHER) to determine better viral epidemiological research in preparation for potential vaccine trials. Provided structure and funding for continuation of Rakai cohort.RHSP Status Report Feb 2007, Fred Nalugoda 
461999RCCS cohort W1 beganStudiesRange: 6 Apr 1999 - 14 Feb 2000Regions and Communities 
  1999KYOTERA (001) 045 PickCommunitiesKYOTERA CENTRAL picked up during W1 (1999-2000)Regions and Communities 
  1999KYOTERA (001) 046 PickCommunitiesKYOTERA LUBIRA picked up during W1 (1999-2000)Regions and Communities 
  1999KYOTERA (001) 755 DropCommunitiesKIBIRA, Bijja, Bikira, Gayaza, Kiteredde dropped during W1 (1999-2000)Regions and Communities 
  1999KIBALE\RAKAI (003) 044 DropCommunitiesKIBAALE TC. Dropped during W1 (1999-2000)Regions and Communities 
  1999KIBALE\RAKAI (003) 084 DropCommunitiesRAKAI TC. Dropped during W1 (1999-2000)Regions and Communities 
  1999KIBALE\RAKAI (003) 901 DropCommunitiesRAKAI HIGH S.S.S dropped during W1 (1999-2000)Regions and Communities 
  1999KATANA (006) 061 DropCommunitiesKIRUMBA, Kyakalera, Kabasumba, Butembe dropped during W1 (1999-2000)Regions and Communities 
  1999KATANA (006) 065 DropCommunitiesKYAKUDDUSE, Kasambya, Nkenge dropped during W1 (1999-2000)Regions and Communities 
  1999BUYAMBA (007) 060 DropCommunitiesKISAAYITC dropped during W1 (1999-2000)Regions and Communities 
  1999LWANDA (008) 032 DropCommunitiesBUTIITI TC. Dropped during W1 (1999-2000)Regions and Communities 
  1999LWANDA (008) 035 DropCommunitiesLWANDA TC. Dropped during W1 (1999-2000)Regions and Communities 
  1999KASASA/SANJE (009) 014 PickCommunitiesNAKATOOKE, Kijonjo picked up during W1 (1999-2000)Regions and Communities 
  1999KASASA/SANJE (009) 015 PickCommunitiesKIRUULI TC. Picked up during W1 (1999-2000)Regions and Communities 
  1999LWAMAGGWA (010) 020 PickCommunitiesNTALULE picked up during W1 (1999-2000)Regions and Communities 
  1999LWAMAGGWA (010) 021 PickCommunitiesLWOYO picked up during W1 (1999-2000)Regions and Communities 
  1999LWAMAGGWA (010) 031 PickCommunitiesLUGALAMA picked up during W1 (1999-2000)Regions and Communities 
  1999LWAMAGGWA (010) 052 DropCommunitiesLWENTULEGE, Kyaluyimuka dropped during W1 (1999-2000)Regions and Communities 
  1999LWAMAGGWA (010) 053 DropCommunitiesKAAPA KASAMBYA dropped during W1 (1999-2000)Regions and Communities 
  1999LWAMAGGWA (010) 468 DropCommunitiesKACHERA, Kibaati, Katovu, Buyojwa dropped during W1 (1999-2000)Regions and Communities 
  1999LYANTONDE (011) 001 PickCommunitiesLYANTONDE -KALIIRO picked up during W1 (1999-2000)Regions and Communities 
  1999LYANTONDE (011) HS 022 PickCommunitiesLYANTONDE-KOOKI picked up during W1 (1999-2000)Regions and Communities 
  1999LYANTONDE (011) HS 027 PickCommunitiesMUKOKOMA picked up during W1 (1999-2000)Regions and Communities 
  1999LYANTONDE (011) HS 030 PickCommunitiesKYAMUSAALE picked up during W1 (1999-2000)Regions and Communities 
  1999MER and CHER Studies funded by Walter Reed Army Institute of ResearchFundingGrants 3 years of funding (W1-W3), focused on continuing cohort follow-up and exploring community attitude toward HIV vaccine testing (CHER). When cohort participants become seropositive, perform viral epidemiology on HIV subtypes, recombinants, viral set points (MER)RHSP Status Report Feb 2007, Fred Nalugoda 
  1999MER protocols require cell sortingLab testsWhole blood sent to Entebbe daily via boda for sorting for MER protocolSarah, Margaret - lab 
  1999CHER (or RCCS) questionnaire modifiedQuestionnairesCHER questionnaire used at baseline visit modified to includes additional questions about interest in vaccine.QC team 
  1999MER questionnaires createdQuestionnairesIf subject seroconverts while enrolled in CHER, had additional MER questionnaire administered. Includes more frequent follow up and in depth questions about seroconversion.QC team 
  1999VCT questions added to RCCS questionnairesQuestionnairesAdded questions about receipt of voluntary HIV counseling and testing (VCT)QC team 
  1999Domestic violence questions added to RCCS questionnairesQuestionnairesAdded questions about perceptions, occurrences of domestic violence in home and communityQC team 
  1999MER study beganStudiesHIV Molecular Epidemiologic Study (MER) focused on immunological and epidemiological research to better understand how HIV progresses. Specifically focused on post-seroconversion peak viremia, viral set-points, sequencing.Fred Nalugoda, QC team 
2152000RCCS cohort W2 beganStudiesRange: 15 Feb 2000 - 19 Feb 2001Regions and Communities 
8 2000Bacterial Vaginosis Study funded by NIAIDFundingNIAID provides 5 years funding for Bacterial Vaginosis: Etiology and Sexual Transmission Study to follow natural history of BV in women and study effects of changes in flora on HIV riskRHSP Status Report Feb 2007, Fred Nalugoda 
  2000KYOTERA (001) 045 DropCommunitiesKYOTERA CENTRAL dropped during W2 (2000-2001)Regions and Communities 
  2000KYOTERA (001) 046 DropCommunitiesKYOTERA LUBIRA dropped during W2 (2000-2001)Regions and Communities 
  2000LWANDA (008) 900 DropCommunitiesKAMMENGO TECH.INST. Dropped during W2 (2000-2001)Regions and Communities 
  2000KASASA/SANJE (009) 014 DropCommunitiesNAKATOOKE, Kijonjo dropped during W2 (2000-2001)Regions and Communities 
  2000KASASA/SANJE (009) 015 DropCommunitiesKIRUULI TC. Picked up during W2 (2000-2001)Regions and Communities 
  2000LWAMAGGWA (010) 020 DropCommunitiesNTALULE dropped during W2 (2000-2001)Regions and Communities 
  2000LWAMAGGWA (010) 021 DropCommunitiesLWOYO dropped during W2 (2000-2001)Regions and Communities 
  2000LWAMAGGWA (010) 031 DropCommunitiesLUGALAMA dropped during W2 (2000-2001)Regions and Communities 
  2000LYANTONDE (011) HS 027 DropCommunitiesMUKOKOMA dropped during W2 (2000-2001)Regions and Communities 
  2000LYANTONDE (011) HS 030 DropCommunitiesKYAMUSAALE dropped during W2 (2000-2001)Regions and Communities 
  2000Fertility Data Analysis funded by NIHFundingfunded for 2 yearsRHSP Status Report Feb 2007, Fred Nalugoda 
  2000Opinion Leader (OL) Study funded by NIMHFundingfunded for 5 yearsFred Nalugoda, Julia Cummiskey 
  2000Rakai Project funded as HIV Prevention Trails Network (HPTN) siteFundingfunded by NIH as HPTN site for 1 yearRHSP Status Report Feb 2007, Fred Nalugoda 
  2000HPV and cervical cancer study funded by NCIFundingNCI provides 2 years of funding for the sudy of natural histor of HPV infection and cervical cancerRHSP Status Report Feb 2007, Fred Nalugoda 
  2000Module for family planning added to RCCS questionnaireQuestionnairesAdded 1 module for males, females. Focused on gauging interest in family planning, and current contraception useQC team 
  2000Opinion leader questionnaire createdQuestionnairesIndependent short version questionnaire created with questions focused on finding who the opinion leaders were, and who they worked withQC team 
  2000Effects of HIV on Fertility Study beganStudiesCollected and analyzed data from RCCS on the demographic and social effects of HIV-related reductions in fertilityRHSP Status Report Feb 2007 
  2000Community Opinion Leader Study beganStudiesMulti-center HPTN qualitative study to assess sexual and social networks to determine how to help people uptake services and reduce HIV infectionsQC team 
432001RCCS cohort W3 beganStudiesRange: 3 Apr 2001 -31 May 2002Regions and Communities 
  2001Preparation for New HIV Prevention Strategies funded by Gates FoundationFunding1 year of funding for a pilot study to support HIV prevention strategies, including male circumcisionRHSP Status Report Feb 2007, Godfrey Kigozi 
  2001pMTCT NVP study funded by Elizabeth Glaser Pediatric AIDS FoundationFunding3 years of funding. RHSP funded to explore ways to reduce pMTCT transmissionRHSP status report Feb 2007, Joseph Kagaayi 
  2001BV assessment questionnaires createdQuestionnairesRCCS questionnaire used at baseline visit, regardless of if person was in cohort, then independent questionnaires with questions about water source, animals in house, genital washing procedures. Administered baseline form, then short f/u form weekly for 1 month, then long f/u form at 1 month and 1 yearQC team 
  2001BV Natural History Study beganStudiesDetermine factors associated with high BV prevalence in Rakai in womenRakai_Report_2010 
  2001NVP study beganStudiesNVP syringes for mothers and infants provided to HIV+ mothers to administer at homeRHSP status report Feb 2007 
  2001Home-based provision of sdNVP beganTreatmentsdNVP provided to mothers for pMTCTJoseph Kagaayi 
7152002RCCS cohort R9 beganStudiesRange: 15 Jul 2002 - 1 Aug 2003Regions and Communities 
8 2002Parallel EIA, Discordant: Rapid for HIV testingLab testsDue to difficulty of obtaining WB kits, Rapids were used as a tie breaker for discordant EIAs in the period of August 2002 and September 2003History of HIV Testing Algorithms 
9 2002Male Circumcision for HIV Prevention trial funded by NIAIDFundingfunded for 5 years. Determine whether post-pubertal MC reduces HIV and STI acquisitionRHSP Annual Report 2003-2004, Godfrey Kigozi 
10 2002Randomized Trial of Male Circumcision, STD, HIV and Behavioral Effects in Men, Women and the Community' Study funded by Gates FoundationFundingFunded for 5 years. Assess the safety and STD effects of MC in HIV+ men, effect on their female partners STD risk, and behavioral effects.RHSP Annual Report 2003-2004, Godfrey Kigozi 
  2002Began using HIV Rapid testsLab testsRapid HIV tests were introduced in order to screen subjects for MC trialsGray et al 2007 Limitations of rapid HIV-1 tests... 
  2002RHSP designated part of ICEROtherNIAID declares RHSP to be part of Uganda's International Center of Excellence in Research (ICER)  
  2002Modules for males added for BV Polygamous study createdQuestionnairesAdded modules for males to supplement female BV modules also containing questions about water source, animals in house, genital washing proceduresQC team 
  2002AnthropometryStudiesFind alternative ways of measuring gestation age of newborns - measure heads, chest circumference & weightJoseph Kagaayi 
  2002BV PolygamousStudiesAssess factors involved in BV in female with multiple partners, or with male partners with multiple female partnersQC team 
  2002HPV study began StudiesAnalyze self-collected vaginal swabs administered to women followed in RCCS in order to determine prevalence, incidence, and clearance of high-risk HPV infectionsMark-Sklar & Dr. Murokora 
7 2003Sexual satisfaction, hygeine questions added to RCCS questionnaireQuestionnairesAdded questions about sexual satisfaction, hygeine to main RCCS questionnaires.QC team 
9 2003Parallel EIA, Discordant: WB for HIV testingLab testsResumed 2 EIA's run in parallel with discordants run on WBHistory of HIV Testing Algorithms 
9262003RCCS cohort R10 beganStudiesRange: 26 Sep 2003 - 23 Nov 2004Regions and Communities 
11 2003MC pilot study beganStudies200 HIV negative men enrolled in NIH pilot study before roll-out of main protocolGodfrey Kigozi 
  2003NIAID ICER provides support for laboratory research activities at RHSPFundingAward provides ongoing laboratory support (equipment, technical assistance, supplies). Permits infrastructure for assessment of HIV viral load, HIV sequencing and transmission linkages, genotypingRHSP Annual Report 2003-2004 
  2003construction of new Rakai Health Sciences Center funded by Doris DukeFundingDoris Duke Charitable Foundation funds construction of new RHSP center in KalisizoRHSP Status Report Feb 2007 
  2003Abstinence until marriage became dominant strand of ABC education in UgandaOtherSex education and condom promotion in Uganda became less mainstream than when the ABC model was initially introducedhttp://www.hrw.org/sites/default/files/reports/uganda0305.pdf 
  2003Information Technology capabilities increasedOtherOver 40 desktop computers and 10 laptops connected to broadband internet via satellite dish at Kalisizo StationRHSP Annual Report 2003-2004 
  2003Male circumcision questions added to RCCS questionnaireQuestionnairesFor MC pilot study, questions about acceptibility, safety, perceptions about MC added into RCCS baseline questionnaire.QC team 
  2003Benefits survey and qualitative component questionnaires createdQuestionnairesIndependent questionnaires created for survey component and qualitative component administered at 2 timepoints to randomly selected subjects in Rakai cohort, with questions focusing on determining what motivates people to participate in studies with or without financial incentive. QC team 
  2003Modules for ARVs added to RCCS baseline, f/u questionnairesQuestionnairesQuestions focus on attitude, acceptibility, knowledge of ARTQC team 
  2003Benefits and Risks StudyStudiesDetermine subject's perceptions on their benefits, risks from study participationQC teamJennifer Wagman, Ezekiel Emanuel
  2003Malaria and HIV coinfection study beganStudiesIn collaboration with ICER, John Hopkins Malaria Institute funds 1 year study of HIV and malaria co-infection during pregnancy and the effects on MTCTRHSP Status Report Feb 2007 
  2003SOCERNETStudiesSocial and Ethnographic Research on Networks and Community Opinion Leaders was a downsized version of the original OL study that was better tailored to fit the needs of Rakai district. Facilitation of in depth interviews to help identify popular opinion leaders who could become agents of behavioral change.RHSP Annual Report 2003-2004Willow (NIMH)
6 2004Uganda began to offer free ARVs to those who qualified for treatmentHIV CareARV initiation for WHO stage I, II, III in people with CD4<200; ARV initiation for WHO stage IV irrespective of CD4. ART rollout initially funded by World Bank, The Global Fund, and PepfarUganda MOH HIV treatment guidelines 
6 2004RHSP began ART deliveryHIV CarePEPFAR funds the start of ART delivery. Service program provided ART, HCT, CD4 screening, pMTCT, HIV-related careGertrude Nakigozi 
6 2004SUUBI mobile clinics provided ART and HIV care to communityHIV Caremobile Suubi "Hope" clinics that visit communities biweekly and provide HIV care and general health careGertrude Nakigozi 
6 2004MOH guidelines for ARV initiation CD4<200Treatment1st line: 2 NRTI+1 NNRTI, 2nd line: 2 NRTI+1 PIUganda MOH HIV treatment guidelines 
6 2004RHSP ARV initiation to patients with CD4<250TreatmentRHSP establishes ARV roll out to patients with CD4<250, after site visit to a home-based care program in Tororo. 1st line: 2 NRTI+1 NNRTI, 2nd line: 2 NRTI+1 PIGertrude Nakigozi 
9 2004Assessing ARV Effects Study funded by NIH Offices of AIDS ResearchFundingNIH OAR provides funding for 1 year to study effects of ARVs on HIV epidemiology and behaviors in RCCS participantsRHSP Status Report Feb 2007 
11 2004New f/u versions of MC forms created for MC TrialsQuestionnairesRCCS questionnaire used for baseline, then for trial participants, short form and long form created. Questions focused on genital washing, acceptibility, sexual satisfaction, info detailing MC procedure. After subjects enrolled at baseline, short forms administered at Day 1, Week 1, weekly thereafter for next 6 weeks in intervention arm. Long form administered at 6 month, 1 year, 2 years in both control and intervention armQC team 
  2004Rakai Project renamed Rakai Health Sciences ProgramOther   
  2004Maximaster MKII incinerator installed at Kalisizo StationOtherAllowed RHSP to dispose biological waste in efficient method with minimal environmental pollutionRHSP Annual Report 2003-2004 
  2004Male circ trial (NIH)StudiesMC in HIV- men for HIV & STI preventionRakai_Report_2010 
  2004Male circ & behavior trial (Gates)StudiesMC in HIV-, HIV+ men for STI prevention, spousal risk assessmentRakai_Report_2010 
2152005RCCS cohort R11 beganStudies Range: 15 Feb 2005 - 30 Jun 2006Regions and Communities 
5 2005New RHSP laboratory equipped with greater serology laboratory capabilityLab testsNew serology laboratory can process: HIV EIA, WB, CrAG, HAV, HBV, HCV, syphilis RPR and TPPA, toxo, ELISPOTRHSP Status Report 2007 
5 2005New RHSP laboratory equipped with greater clinical chemistry laboratory capabilityLab testsUsing Selectra blood chemistry analyzer, new clinical chemistry laboratory can process: serum electrolyte, liver, pancreatic and renal functionRHSP Status Report 2007 
5 2005New RHSP laboratory equipped with greater molecular biology laboratory capabilityLab testsNew molecular biology laboratory can process: HIV PCR, VL, CT/GC, HPV, CMV, real time PCR, MHARHSP Status Report 2007 
5252005Roche Amplicor HIV-1 Monitor 1.5 used for HIV viral loadLab testsAssess HIV-1 viral load using Roche Amplicor HIV-1 Monitor Test. Lower limit of detection <400 cpmSarah Kalibbala- lab 
5 2005New RHSP laboratory expands capability in other technologyLab testsIn addition to new serology, chemistry, molecular bio technology, new lab equipped to process hematology (Coulter), flow cytometry (FACS count), microbiology, mycobacteriology, mycology, parasitology, tissue/cell culture, pathology, media preparationRHSP status report Feb 2007 
5 2005Rakai Health Sciences Center opened in KalisizoOther   
8 2005The Global Fund suspended funding to Uganda for ART roll outFundingAug 2005-Nov 2005, funding for ART frozen after financial irregularities and mis-allocation of funds towards non-HIV/AIDS activities were discovered.www.theglobalfund.org; www.avert.org/hiv-aids-uganda.htm 
8 2005SHARE Project beganStudiesBuild networks for mutual support, establish violence prevention policies to decrease interpersonal violence and sexual coercionRCCS-postcirc-share ProtocolJennifer Wagman
11 2005VLM beganHIV careViral load monitoring first became used at RHSP for routine monitoring of all ART clients. Assess virological failure rates in subjects every 3 mon for 1st year after ART initiation, and every 6 months thereafter.ICER report 2013 
  2005KALISIZO (002) 009 PickCommunitiesBUKUNDA\KABUWOKO picked up during R11 (2005-2005)Regions and Communities 
  2005KATANA (006) 256 PickCommunitiesKITO-NKOKKO, Kasaka, Lutoma picked up during R11 (2005-2005)Regions and Communities 
  2005ARV Effects on HIV Epidemiology and Behaviors funded by NICHDFundingfunded for 5 years. Provides sufficient resources for maintaining RCCS and continuing to assess questions about effects of ARV rollout on community rates of HIV, morbidity, mortality, fertility, pMTCT, ARV acceptance/adherence, stigma, drug resistant strainsRHSP status report Feb 2007 
  2005Morbidity/Mortality and Disability in Children Study funded by Fogarty International Center and NIHFundingfunded for 4 yearsFred Nalugoda, Julia Cummiskey 
  2005Up-Hold Study funded by USAIDFunding2 years of funding granted, but after unrealistic expectations expressed by funders, RHSP returned grant moneyFred Nalugoda 
  2005Basic care program began HIV Caretx for OI, ctx, bed nets, clean water provided to patients ineligible for ARTRakai_Report_2010 
  2005Separate questionnaire modules created for Armis studyQuestionnairesIndependent questionnaire created to assess growth rates, birth rates, questions pertaining to pediatric illnessesQC team 
  2005Armis StudyStudiesA continuation of the NVP study, and complementary to MISS study, allowing continued intensive education and access to care. Program starts offering mothers free infant formula, clean vacuum flasks, instructions on use as alternative to breastfeeding.QC team, Joseph Kagaayi, Fred Nalugoda 
  2005ARCSStudiesART-Related Clinical Study to measure ARV adherence and the effects on community HIV-related behaviorsRakai_Report_2010 
  2005Up-HoldStudiesStudy aimed to document trends in HIV, mortality, fertility, and effect on behavior. Funding not alloted for prospective study, so funding returned and study not started.Fred Nalugoda 
5 2006Peer health worker and mobile phone program beganStudiesPilot study to assess impact of PHW and warmline staffed by clinicians to improve HIV care. Pilot study ranged May 2006-July 2008Gertrude, Larry 
8302006RCCS cohort R12 beganStudiesRange: 30 Aug 2006 - 24 Apr 2008Regions and Communities 
1112006Study of Febrile HIV Subjects BeganStudiesAssess infectious causes of fever and their effects among clinic participantswww.jhsph.edu/research/centers-and-institutes/rakai-health-sciences-program 
  2006KABIRA (004) 183 PickCommunitiesBAKKA, BWAMIJJA, NZIRIZI picked up during R12 (2006-2008)Regions and Communities 
  2006Pilot testing of HIV Rapid tests beganLab testsBefore Rapid tests routinely used for HIV testing for cohort or service clients, started pilot study to evaluate reliabilityFred Nalugoda 
  2006Began using Binax Now Malaria Test Lab testsUsed Binax Now rapid detection test for malaria results at mobile clinicsSarah Kalibbala- lab 
3 2007Scale up of MC in high prevalence countries recommended by WHO and UNAIDSOtherIn countries with HIV prevalence rates >3% and generalized heterosexual HIV epidemics, it was recommended that male circumcision become part of the HIV prevention packagehttp://www.who.int/mediacentre/news/releases/2007/pr10/en/ 
9 2007pMTCT guidelines changed to WHO recommendationsTreatmentAZT/3TC starting at 28 weeks of pregnancy + sdNVP for mother and infant; 7 days AZT/3TC post birth administered to mtherJoseph Kagaayi 
10122007Switched to Roche COBAS chemistry analyserLab testsAssess clinical chemistry and immunochemistry measures by COBAS analyzer seriesSarah, Margaret - lab 
11 2007Switched to FACSCaliber for flow cytometryLab testsCD4/CD8/CD3 evaluated using FACSCalibur. 2 machines available and determination of use is study-specificSarah Kalibbala- lab 
  2007Post Circ Trial funded by NIAIDFundingNIAID provides 5 years of funding to study post trial epidemiological and behavioral surveillance in men enrolled into MC for HIV prevention trialRHSP Status Report Feb 2007, Godfrey Kigozi 
  2007Altered circumcision questions on RCCS questionnaireQuestionnairesAdded questions to assess sexual satisfaction after MC procedure for both males, females.QC team 
  2007ARV module edited on RCCS questionnaireQuestionnairesChanged questions about ART to ask about acceptibility of ART, knowledge of protection, satisfaction with ARTQC team 
  2007HSV questionnaires createdQuestionnairesIndependent enrollment form, f/u form created for males and females focusing on HSV-related questions, examination outcomes, genital cleaning. Administered at baseline, every month thereafter up to 24 monthsQC team 
  2007Post Circ Trial beganStudiesAssess long-term effects of MMC, effect on risk behaviors, HIV incidence, and foreskin immunology.RCCS-postcirc-share Protocol, RHSP status report Feb 2007, Godfrey Kigozi 
  2007Discordant studyStudiesMeasure effect of ART initiation, counseling and risk reduction to serodiscordant couplesRakai_Report_2010 
  2007Madic study beganStudiesAssess neurodevelopment in HIV-exposed childrenJoseph Kagaayi 
  2007HSVStudiesRCT of HSV suppression in slowing HIV disease progression in ART-naïve subjectsRakai_Report_2010 
  2007Intensive MC follow-up studyStudiesIntensive f/u component of post circ trial to evaluate effect of MMC on PVL, wound healing, safety. RHSP status report 
662008RCCS cohort R13 beganStudiesRange: 6 Jun 2008 - 7 Dec 2009Regions and Communities 
7 2008PeerSMART program Began HIV CareExpert patient treatment support began after successful pilot studyGertrude Nakigozi 
11 2008Used Murex and ETI kits for HBV studyLab testsMurex test used for HBsAg, ETI test for core AgSarah Kalibbala- lab 
  2008KALISIZO (002) 009 DropCommunitiesBUKUNDA\KABUWOKO dropped during R13 (2008-2009)Regions and Communities 
  2008HBVStudiesAssess prevalence of HBV, cirrhosis, and fibrosis in HIV+ and HIV- subjectsRakai_Report_2010 
412009Serial EIA, Discordant: Rapid for HIV testingLab testsStarted running EIA's in series and stopped testing participants already tested HIV+ twiceHistory of HIV Testing Algorithms 
412009HIV testing algorithm updatedLab testsMurex test used first; if positive result, then sample run on Vironstika Uniform II plus O. Discordant positives run on WB; if sample gives discordant results, then RNA PCR run.History of HIV Testing Algorithms 
  2009RCCS modules on MC alteredQuestionnairesQuestions about circumcision within RCCS module were reduced because main trials had endedQC team 
  2009Hormonal contraception study beganStudiesDetermine effect of hormonal contraception on virological suppression and HIV-disease progression through retrospective analysisRakai_Report_2010, Fred NalugodaChelsea Polis
  2009Rakai Youth ProjectStudiesAimed to better understand behavioral aspects of adolescents, connection to their risks for HIV, and how to intervene. Used client-centered care to gauge aspirations of youth and use to create interventional education about risk reduction.Fred Nalugoda 
1182010RCCS cohort R14 beganStudiesRange: 18 Jan 2010 - 24 Jun 2011Regions and Communities 
10 2010rapid antigen-capture dipstick testLab testsBegan routinely using rapid testing for malariaSarah Kalibbala- lab 
1042010Abbott RealTime HIV-1 used for viral loadLab testsAssess HIV-1 viral load using Abbott RealTime. Lower limit of detection <50 cpmSarah Kalibbala- lab 
12 2010Malaria surveillance grant funded by NIAIDFundingNCT01265407. Funded for 2 yearsFred Nalugoda, Julia Cummiskey 
  2010KABIRA (004) 183 DropCommunitiesBAKKA, BWAMIJJA, NZIRIZI dropped during R14 (2010-2011)Regions and Communities 
  2010KATANA (006) 256 DropCommunitiesKITO-NKOKKO, Kasaka, Lutoma dropped during R14 (2010-2011)Regions and Communities 
  2010All Ugandan hospitals and HC-IV required to provide HCTOtherResources for HIV counseling and testing mandatory at all hospitals and HC-IV's. Over 2000 healthcare settings facilitate routine or opt-out testingGlobal AIDS Response Progress Report; Country Progress Note Uganda; April 2012 
  2010Nutrition studyStudies Fred Nalugoda 
  2010Genital immunology studyStudiesDetermine correlates of mucosal protection from HIV infection in high risk, serodiscordant HIV uninfected subjectsRakai_Report_2010 
  2010Genital microbiota, inflammation, and riskStudiesStudy genital bacterial communities and inflammatory markers in HIV+ and HIV- subjectsRakai_Report_2010 
  2010MOH switched to Option A for pMTCTTreatmentPregnant mothers with CD4<350 eligible for ARVs. If CD4>350,AZT/3TC starting at 14 weeks gestation, sdNVP at birth+ 7 days AZT/3TCJoseph Kagaayi 
  2010ARV adminstration to infants for 14 weeks for pMTCTTreatmentAfter Armis study concluded, RHSP continued to administer 14 weeks NVP or AZT to infants for pMTCTJoseph Kagaayi 
1172011RHSP staff placed at MOH sites within districtHIV CareIntegration of services encouraged by PEPFAR. Mobile clinics & home visits eliminated, static RHSP staff placed at select health centers (number of clinicians, nurses based on patient load)Gertrude Nakigozi 
1172011Most HC-II dropped from RHSP's patient loadHIV CareWith the exception of Kasensero and Kibale who had unique populations with high patient loads needing access to ARV services, all other HC-II dropped by RHSP and handed over to MOHGertrude Nakigozi 
2 2011ARV initiation CD4<350Treatment1st line: 2 NRTI+1 NNRTI, 2nd line: 2 NRTI+1 PIUganda MOH HIV treatment guidelines 
8102011RCCS cohort R15 beganStudiesRange: 10 Aug 2011- 5 Jul 2013Regions and Communities 
10 2011HIV Rapid testing implementedLab testsIn order to allow for less frequent ELISA testing, Rapids evaluated with EIA (Murex, then followed by confirmatory Vironostika if +, or Vironosticka or Bio Rad if neg, WB used as final confirmatory test for positives).Sarah Kalibbala- lab 
10 2011Parallel Rapid, Discordant: WB for HIV testingLab testsRapid HIV testing validated, and Rapid testing and a third EIA were introduced. Determine and Stat Pak were run in parallel and discordants tested on Unigold.History of HIV Testing Algorithms 
  2011KYOTERA (001) 755(HS) PickCommunitiesNEW KYOTER CENTRAL picked up during R15 (2011-2013)Regions and Communities 
  2011KIBALE\RAKAI (003) 036 DropCommunitiesKYAKAGO/KIBANDA, Bushenyi, Bulanga dropped during R15 (2011-2013)Regions and Communities 
  2011KIBALE\RAKAI (003) 055 DropCommunitiesBYAKABANDA, Kageye, Kyandaaza Katerero dropped during R15 (2011-2013)Regions and Communities 
  2011KIBALE\RAKAI (003) 401 DropCommunitiesBAKIJJULULA, Kamukalo dropped during R15 (2011-2013)Regions and Communities 
  2011KATANA (006) 003 DropCommunitiesKATANA, Buzirandulu, Nvubu, Kirembwe, Kijej dropped during R15 (2011-2013)Regions and Communities 
  2011KATANA (006) 095 DropCommunitiesNABIGASA-Kafunda, Ntovu dropped during R15 (2011-2013)Regions and Communities 
  2011KATANA (006) 109 DropCommunitiesNAKATOOGO-East+West, Byerima, Nakasoga dropped during R15 (2011-2013)Regions and Communities 
  2011KATANA (006) 177 DropCommunitiesBETEREMU, Kituntu, Kibonzi, Kasekere, Kasambya dropped during R15 (2011-2013)Regions and Communities 
  2011BUYAMBA (007) 018 DropCommunitiesKICHWAMANGO, Luwama, Kasansula, Kisaana dropped during R15 (2011-2013)Regions and Communities 
  2011BUYAMBA (007) 025 DropCommunitiesBUYAMBA, Kyondo, Kammengo, Nsonso dropped during R15 (2011-2013)Regions and Communities 
  2011BUYAMBA (007) 059 DropCommunitiesDDWANIRO, Katonto, Kireeta Ntimbe Lutub, Nateete Lutilwanjuki dropped during R15 (2011-2013)Regions and Communities 
  2011BUYAMBA (007) 103 DropCommunitiesKIKUNYU, Kareere A+B dropped during R15 (2011-2013)Regions and Communities 
  2011BUYAMBA (007) 451 DropCommunitiesKAGAMBA,Kimuli dropped during R15 (2011-2013)Regions and Communities 
  2011LWAMAGGWA (010) 054 DropCommunitiesNDEEBA\KATOOGO, Kyabigondo, Kayunga, Lwennanga dropped during R15 (2011-2013)Regions and Communities 
  2011LWAMAGGWA (010) 081 DropCommunitiesLWAMAGGWA dropped during R15 (2011-2013)Regions and Communities 
  2011LWAMAGGWA (010) 760 DropCommunitiesKASANKALA dropped during R15 (2011-2013)Regions and Communities 
  2011KASENSERO (012) 038 PickCommunitiesKASENSERO LANDING SITE picked up during R15 (2011-2013)Regions and Communities 
  2011KASENSERO (012) 370 PickCommunitiesGWANDA, Kinyinga, Lukindu, Misozi, Mirigwe picked up during R15 (2011-2013)Regions and Communities 
  2011KASENSERO (012) 23 PickCommunitiesKYEBEBalole, Muzzi, Katongero picked up during R15 (2011-2013)Regions and Communities 
  2011DDIMO (013) 770 PickCommunitiesMALEMBO, Bwende, Kyamizimba, Kikonda, picked up during R15 (2011-2013)Regions and Communities 
  2011DDIMO (013) 771 PickCommunitiesDDIMU, picked up during R15 (2011-2013)Regions and Communities 
  2011DDIMO (013) 772 PickCommunitiesBBULIRO, picked up during R15 (2011-2013)Regions and Communities 
  2011DDIMO (013) 773 PickCommunitiesBUYAGA Nkoma, Bibaale, picked up during R15 (2011-2013)Regions and Communities 
  2011DDIMO (013) 774 PickCommunitiesNAMIREMBE picked up during R15 (2011-2013)Regions and Communities 
  2011MUTUKULA (014) 051 PickCommunitiesMUTUKUL TC KOLOLO ZONE picked up during R15 (2011-2013)Regions and Communities 
  2011MUTUKULA (014) 776 PickCommunitiesMUTUKULA CENTRAL picked up during R15 (2011-2013)Regions and Communities 
  2011MOH guidelines adapt to regulate use of Rapid tests for HIV testingOtherMOH changed guidelines to use Rapid HIV testingFred Nalugoda 
  2011Alpha demographic analysis investigatedQuestionnairesInvestigated adoption of Alpha questionnaire for verbal autopsies, but found to be too extensive to administer. Truncated version of Alpha questionnaire generated for use with the Rakai cohortFred Nalugoda 
  2011Malaria study questionnaires createdQuestionnairesIndependent questionnaires added with questions about signs, symptoms, presence and history of malaria in the home, current preventive practices, diagnostic test of malaria. Questionnaires administered at baseline, every month thereafter until 1 yearQC team 
  2011RCCS modules on ARVs alteredQuestionnairesQuestions about ARVs reduced because no new information was being captured - education and knowledge of ART was deemed good within communityQC team 
  2011Opthomology in HIV+ individuals studyStudiesAimed to better characterize effect of HIV and/or ARVs on eyesight. Training implemented in clinics and eye charts set up to evaluate long-term effect of HIV and HIV treatment on visionFred Nalugoda 
  2011Malaria Surveillance study (ICER) beganStudiesICER study of epidemiology of malaria in households with children 6 months to 10 years. Administered questionnaires, took blood specimens, and malaria smears for children and primary care givers at baseline, monthly for 1 year. 1600 children enrolled.Enos Baghendaghe 
  2011Malaria IeDEA study beganStudiesFacility based observational study of children <5 years presenting with fever at Kalisizo hospital or HC-III. Aimed to improve lab and staff capacity, estimate prevalence of malaria in febrile children, measure treatment outcomes. 3000 children enrolledEnos Baghendaghe 
  2011Adult ShangringStudiesStudy to monitor safety and acceptibility of shangring device as alternative to MMC. 400 men enrolled over 6 months.Godfrey Kigozi 
1 2012Parallel Rapid, EIA, Discordant: WB for HIV testingLab testsWhen EIA on the Rapid discordants were found to agree with the Unigold result, testing of discordants was halted. History of HIV Testing Algorithms 
182012RCCS cohort R15S beganStudiesRange: 8 Jan 2012 - 18 Mar 2013Regions and Communities 
3 2012Began use of Pima CD4 technologyLab testsPima allowed for teams to measure and immediately report CD4 results to patients in the fieldSarah, Margaret - lab 
4 2012UnijectStudiesCompare intramuscular vs. subcutaneous Uniject injection of hormonal contraception (depo). Assess acceptibility, administration, ease of use for client and provider, effectiveness.Gertrude Nakigozi 
6 2012Enhanced male circumcisicion study funded by NIHFundingIn addition to monitoring effect of MC on HIV incidence, train midwives to perform early infant circumcisicion, and perform on 500 infantsGodfrey Kigozi 
6 2012Enhanced male circumcisicion study beganStudiesAssess effect of MC on HIV incidence by monitoring cohorts. Evaluate effect of early infant MC on HIV trends/careGodfrey Kigozi 
9 2012Parallel Rapid, 3 EIA, Discordant: EIA/RNA PCR for HIV testingLab testsAdjustment was made in that both Vironostika (Uniform) and Biorad could be used as the 2nd or 3rd EIA depending on availability. Bio Rad better utilized as 2nd EIA since kits were larger, more cost effective.History of HIV Testing Algorithms 
9142012MOH switched to Option B+ for pMTCTTreatmentPregnant mothers eligible for ARVs regardless of CD4 count or clinical stagingJoseph Kagaayi 
  2012Linkage Study fundedFundingFunded for 5 years. Enables follow up of RCCSGodfrey Kigozi, Fred Nalugoda 
  2012Opthomology outreach beganHIV CareFree cataract surgery provided at 3 mobile clinicsGertrude, Fred 
  2012Clinical chemistry not as routinely usedLab testsDue to decreases in PEPFAR funding, reagents for clinical chemistry not purchased as routinely and panels run less frequentlySarah Kalibbala- lab 
  2012OpenMRS version 1.6.3 installedOtherAll RHSP health centers and central processing equipped to use OpenMRS to maintain electronic patient HIV care recordsAnthony Ndayanabo 
  2012Mobility module added to RCCS questionnaireQuestionnairesAdded sexual partner mobility tool to RCCS cohort to track movement of sexual partners associated with fishing communitiesQC team 
  2012HPV ClearanceStudiesMeasure high risk HPV in HIV+ women before and after ARTICER report 2013 
  2012Linkage StudyStudies5 year study to monitor demographics, reproductive health services, HIV education of Rakai district. Retrospective quantitative component and prospective qualitative component to analyze risk behaviors for HIV acquisition.Tom Lutalo, Fred Nalugoda 
  2012Problem with Men StudyStudiesQualitative study to find out why men do not seek care (especially with regards to HIV care)Godfrey Kigozi 
  2012PrepexStudiesStudy to monitor safety and acceptibility of prepex device as alternative to MMC. 350 men enrolled over 6 months.Godfrey Kigozi 
  2012MOH adopts Option B for pMTCTTreatmentPregnant mothers with CD4<350 eligible for ARVs. If CD4>350, AZT/3TC starting at 14 weeks gestation, sdNVP at birth+ AZT/3TC until breastfeeding cessationJoseph Kagaayi 
  2012ARV adminstration to infants changed to 6 weeks for pMTCTTreatmentMOH changed guidelines to administer 6 weeks of ARVs (AZT or NVP) to infants for pMTCTJoseph Kagaayi 
1 2013Parallel Rapid, 2 EIA, Discordant: RNA PCR for HIV testingLab testsNo third EIA performed. Two EIA will follow the rapids and any discordant will go for RNA PCR.History of HIV Testing Algorithms 
1 2013Pima used during RCCS surveyLab testsDuring R16, surveyors performed CD4 monitoring by Pima to supplement HIV testing during round surveySarah, Margaret - lab 
172013RCCS cohort R16 beganStudiesRange: 7 Jan 2013 - still onRegions and Communities 
7 2013Stylish Man study beganStudiesMulembe Mambe campaign initiated to destigmatize MC in older populationsVeena Billoux 
9 2013RHSP starts to transfer management of health centers to district, while maintaining support and supervisionHIV CareEncouraged by PEPFAR, RHSP evaluates district's readiness to takeover health centers, trains MOH workers, and starts to transfer health centers to district. Gertrude Nakigozi 
9 2013Kasensero and Kibale continue to be staffed by RHSPHIV CareSince MOH maintained status of health centers at Kasensero and Kibale as HC-II, RHSP keeps staff stationed at sites in order to administer much needed ARV care deliveryGertrude Nakigozi 
11 2013Pregnancy Malaria Study beganStudies3 year study to test for malaria antibodies to see if possible to produce malaria vaccine for pregnant women. Target N=1100 mothers to be enrolled at maternity ward and antenatal clinicEnos Baghendaghe 
12 2013Rapid serial HIV testing instead of parallel was started for all service clients. Lab testsParallel Rapid HIV testing maintained for cohort clients, but lab switched to serial Rapid testing for service clientsHistory of HIV Testing Algorithms 
  2013Penile epithelial study funded by NIHFundingMeasure and compare moisture levels in different penile regions in circumcised and uncircumcised menGodfrey Kigozi 
  2013Death in Adults study fundedFundingRetrospective analysis of mortality trends fundedGodfrey Kigozi 
  2013Fogarty training grants fundedFunding4 year training grant fundedGodfrey Kigozi 
  2013Switched to Monolisa Anti-HB test for HBVLab testsLiver study protocol dictated use of Monolisa test for HBVSarah, Margaret - lab 
  2013Pregnancy Malaria Study questionnaire createdQuestionnairesIndependent questionnaire created. Only administered once to each participant: focused on questions about pregnancy, prophylaxis, indications for malaria, current complaintsQC team 
  2013Liver Biopsy StudyStudiesExamine the etiology of accelerated liver disease in HIV+ subjectsICER report 2013 
  2013Neuro Study beganStudiesAssess CNS events in 3 groups: ART naïve CD4<200, ART suppressed, HIV negativeQC team 
  2013Adolescent shangringStudiesStudy to monitor safety and acceptibility of shangring device as alternative to MMC. 350 adolescent men enrolled over 6 months.Godfrey Kigozi 
  2013RCCS cohort HTS15 beganStudiesRange: 2013 - 2013Regions and Communities 
  2013Stylish Man study beganStudiesRange: 2013 - still onRegions and Communities 
2 2014Study to test new device for traditional male circumcision beganStudiesAssessed 50 men at intake visit to test device to measure penile circumference for potential used during MMC. Study spanned only 2 weeks.Godfrey Kigozi 
2 2014ARV initiation CD4<500Treatment1st line: 2 NRTI+1 NNRTI (pref TDF/3TC/EFV). Secondary: AZT/3TC/EFV, AZT/3TC/NVP, TDF/3TC/NVP. 2nd line: 2 NRTI+1 boosted PIUganda MOH HIV treatment guidelines 
4 2014Pilot study of prepex funded by CDCFundingCDC funds roll-out of Prepex to community. 400 people over 3-4 monthsGodfrey Kigozi 
4 2014Penile epithelial study beganStudiesCompare moisture levels on outer foreskin, inner foreskin, and glands in both circumcised (MMC) and uncircumcised menGodfrey Kigozi 
5 2014Kibale, Kasensero HC upgraded to HC-IIIsHIV careKibale, Kasensero and 4 other HC-II with high risk communities upgraded to HC-IIIs by MOHFred Nalugoda 
  2014Combination HIV Prevention Evaluation funded by World BankFundingWorld Bank provides funding for cross sectional evaluation of comination HIV prevention.Godfrey Kigozi



 

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